An integrated computational-experimental method to redesign protein dynamics
Funder: Leverhulme TrustDuration: December 2017 - November 2020
Synthetic biology is aimed at introducing changes in organisms to redesign their biological functions. For example, building new materials from nano-scale bacterial fibres. Most biological functions are performed by proteins, that are like small machines with moving parts. However, unlike an engine, their shape constantly change through a process called dynamics. As this is integral to how proteins work, the most desirable way to modify protein function would be to change how they move. In this project, we will develop and apply a novel approach to design protein dynamics based on cycles of computer predictions and experiments in the lab.
People
| Name | Telephone | Office | ||
|---|---|---|---|---|
|
Dr Alessandro Pandini Senior Lecturer in Computer Science (Principal investigator)
T: +44 (0)1895 268045
E: alessandro.pandini@brunel.ac.uk |
+44 (0)1895 268045 | alessandro.pandini@brunel.ac.uk |
Outputs
Li, T., Motta, S., Stevens, AO., Song, S., Hendrix, E., Pandini, A. and et al. (2022) ''. JACS Au, 2 (8). pp. 1935 - 1945. ISSN: 2691-3704
Motta, S., Callea, L., Bonati, L. and Pandini, A. (2022) ''. Journal of Chemical Theory and Computation, 18 (3). pp. 1957 - 1968. ISSN: 1549-9618
Motta, S., Pandini, A., Fornili, A. and Bonati, L. (2021) ''. Journal of chemical theory and computation, 17 (4). pp. 2080 - 2089. ISSN: 1549-9618
Portlock, TJ., Tyson, JY., Dantu, SC., Rehman, S., White, RC., McIntire, IE., et al. (2020) ''. Frontiers in Molecular Biosciences, 7 (112). pp. 1 - 17. ISSN: 2296-889X